Dr Yen Shih-Cheng

Innovation and Design Programme,
Faculty of Engineering, NUS

Research Interests:

Neural Coding, Neuroprosthetics and Tele-health

Email: eleys@nus.edu.sg
Contact: 65162118


Dr. Yen Shih Cheng received his B.S.E. and M.S.E. in 1993, and his Ph.D. in 1998, all from the Department of Bioengineering at the University of Pennsylvania. For his PhD, he worked on neural network models of the primary visual cortex. He then spent several years performing single-neuron recordings in the primary visual cortex of both anesthetized cats and awake, behaving non-human primates, first as a post-doctoral fellow at the University of California, Davis, and subsequently as a Research Assistant Professor at Montana State University. He was previously with the Department of Electrical and Computer Engineering at the National University of Singapore (NUS), and the Deputy Director of the Singapore Institute for Neurotechnology (SINAPSE) at NUS.

As a result of the work done with several years of students, Dr. Yen started a company (T-Rehab) with 2 other NUS colleagues in 2016 that licensed the tele-rehabilitation system developed in NUS. The company was subsequently engaged by the Ministry of Health in October 2016 to roll out the tele-rehabilitation system to multiple hospitals and rehabilitation centers in Singapore.

Research Interests

Neural coding, neuroprosthetics, and tele-health

Personal Interests

Playing softball, watching sports and movies


  • McDonnell-Pew Cognitive Neuroscience Program Individual Grants-In-Aid (1998) (one of 23 awarded in the US in 1998)
  • NIH NRSA Fellowship (1998-2001)
    Solomon R. Pollack Award for Best Ph.D. Dissertation (1998)
  • Whitaker Foundation Graduate Fellowship (1993-1998) (one of 29 awarded in the US in 1993)
  • Philadelphia Young Engineer Award (1993)
  • Rose Prize for Outstanding Undergraduate Research, University of Pennsylvania (1993)
  • NASSAU Award for Undergraduate Research, University of Pennsylvania (1993)


  • An Apparatus and Method for Quantifying Rehabilitation Exercises Including the Detection of Motor Compensation (Converted)
  • Method and Apparatus for Assisting Movement Rehabilitation (Entered into National Phase)
  • Multi-Channel Neural Signal Amplifier System Providing High CMRR Across An Extended Frequency Range (Granted)
  • Bioamplifier System Having High CMRR Extended To A Higher Frequency Range (Converted)
  • A Method for Real-Time Mobile Vital Signs Monitoring and Indoor Localization without On-Body Gateway (Pending)

Selected Research Papers

(corresponding author role is highlighted in bold, *indicates joint corresponding author)

Neural Coding

  1. Parthasarathy, A., Herikstad, R., Bong, J. H., Medina, F. S., Libedinsky, C.*, & Yen, S. -C.* (2017). Mixed selectivity morphs population codes in prefrontal cortex. Nature Neuroscience, 20(12), 1770-1779. doi:10.1038/s41593-017-0003-2 (IF: 19.91)
  1. Krishnan, S., Mathuru, A. S., Kibat, C., Rahman, M., Lupton, C. E., Stewart, J., Claridge-Chang, A., Yen, S. -C., & Jesuthasan, S. (2014). The Right Dorsal Habenula Limits Attraction to an Odor in Zebrafish. Current Biology, 24(11), 1167-1175. doi:10.1016/j.cub.2014.03.073 (IF: 9.25)
  2. Herikstad, R., Baker, J., Lachaux, J. -P., Gray, C. M., & Yen, S. -C. (2011). Natural Movies Evoke Spike Trains with Low Spike Time Variability in Cat Primary Visual Cortex. Journal of Neuroscience, 31(44), 15844-15860. doi:10.1523/JNEUROSCI.5153-10.2011 (IF: 5.97)
  3. Yen, S. -C., Baker, J., & Gray, C. M. (2007). Heterogeneity in the responses of adjacent neurons to natural stimuli in cat striate cortex. Journal of Neurophysiology, 97(2), 1326-1341. doi:10.1152/jn.00747.2006 (IF: 2.50)
  4. Yen, S. C., & Finkel, L. H. (1998). Extraction of perceptually salient contours by striate cortical networks. Vision Research, 38(5), 719-741. doi:10.1016/S0042-6989(97)00197-1 (IF: 2.07)


  1. Peh, W. Y. X., Raczkowska, M. N., Teh, Y., Alam, M., Thakor, N. V., & Yen, S. -C. (2018). Closed-loop stimulation of the pelvic nerve for optimal micturition. Journal of Neural Engineering, 15(6), 066009. doi:10.1088/1741-2552/aadee9 (IF: 3.92)
  2. Peh, W. Y. X., Mogan, R., Thow, X. Y., Chua, S. M., Rusly, A., Thakor, N. V.*, & Yen, S. -C.* (2018). Novel Neurostimulation of Autonomic Pelvic Nerves Overcomes Bladder-Sphincter Dyssynergia. Frontiers in Neuroscience, 12, 18 pages. doi:10.3389/fnins.2018.00186 (IF: 3.88)
  3. Hassani, F. A., Peh, W. Y. X., Gammad, G. G. L., Mogan, R. P., Ng, T. K., Kuo, T. L. C., Ng, L. G., Luu, P., Yen, S. -C.*, & Lee, C.* (2017). A 3D Printed Implantable Device for Voiding the Bladder Using Shape Memory Alloy (SMA) Actuators. Advanced Science, 4(11), 10 pages. doi:10.1002/advs.201700143 (IF: 12.44)
  4. Lee, S., Peh, W. Y. X., Wang, J., Yang, F., Ho, J. S., Thakor, N. V., Yen, S. -C.*, & Lee, C.* (2017). Toward Bioelectronic Medicine—Neuromodulation of Small Peripheral Nerves Using Flexible Neural Clip. Advanced Science, 4(11). doi:10.1002/advs.201700149 (IF: 12.44)
  5. Libedinsky, C., So, R., Xu, Z., Kyar, T. K., Ho, D., Lim, C., Chan, L., Chua, Y., Yao, L., Cheong, J. H., Lee, J. H., Vishal, K. V., Guo, Y., Chen, Z. N., Lim, L. K., Li, P., Liu, L., Zou, X., Ang, K.
    K., Gao, Y., Ng, W. H., Han, B. S., Chng, K., Guan, C., Je, M., & Yen, S. -C. (2016). Independent Mobility Achieved through a Wireless Brain-Machine Interface. PLOS ONE, 11(11), 13 pages. doi:10.1371/journal.pone.0165773 (IF: 2.77)
  6. Xiang, Z., Sheshadri, S., Lee, S. -H., Wang, J., Xue, N., Thakor, N. V., Yen, S. -C.*, & Lee, C.* (2016). Mapping of Small Nerve Trunks and Branches Using Adaptive Flexible Electrodes. Advanced Science, 3(9), 9 pages. doi:10.1002/advs.201500386 (IF: 12.44)
  7. Xiang, Z., Yen, S. -C., Sheshadri, S., Wang, J., Lee, S., Liu, Y. -H., Liao, L. -D., Thakor, N. V., & Lee, C. (2016). Progress of Flexible Electronics in Neural Interfacing – A Self-Adaptive Non- Invasive Neural Ribbon Electrode for Small Nerves Recording. Advanced Materials, 28(22), 4472- 4479. doi:10.1002/adma.201503423 (IF: 21.95)

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